How to produce N-Desalkylflurazepam?

Desalkylflurazepam, also known as N-desalkyl-2-oxoquazepam, is a long-acting metabolite of the benzodiazepine drug flurazepam. The CAS number of N-Desalkylflurazepam is 2886-65-9.

The analytes of N-Desalkylflurazepam

In 《Effects of a single dose of flurazepam on the sleep of healthy volunteers》, It is hypothesized that decreases in stages 3 and 4 that are generally seen on second administration or withdrawal of flurazepam are due to the major metabolite, N-desalkyl-flurazepam. The analytes consisted of (±)-zopiclone, 2-hydroxyethylflurazepam, 3-hydroxyflunitrazepam, 4-hydroxyalprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, alprazolam, bromazolam, clobazam, clonazepam, clonazolam, delorazepam, deschloroetizolam, diazepam, diclazepam, estazolam, etizolam, flualprazolam, flubromazepam, flubromazolam, flunitrazepam, flunitrazolam, flurazepam, lorazepam, lormetazepam, meclonazepam, methylclonazepam, midazolam, N-desalkylflurazepam, N-desmethylclobazam, N-desmethylflunitrazepam, nitrazepam, nitrazolam, nordiazepam, oxazepam, oxazepam glucuronide, phenazepam, temazepam, triazolam, zaleplon, zolpidem, α-hydroxyalprazolam, α-hydroxymidazolam and α-hydroxytriazolam. Deuterated internal standards (ISTDs) were obtained for twenty-two analytes and consisted of 7-aminoclonazepam-D4, 7-aminoflunitrazepam-D7, alprazolam-D5, clonazepam-D4, delorazepam-D4 , diazepam-D5, estazolam-D5, etizolam-D3, flunitrazepam-D7, flurazepam-D10, lorazepam-D4, midazolam-D4, N-desalkylflurazepam-D4, nordiazepam-D5, oxazepam-D5, phenazepam-D4, temazepam-D5, zaleplon-D4, zolpidem-D7, zopiclone-D4, α-hydroxyalprazolam-D5 and α-hydroxymidazolam-D4.

How to produce N-Desalkylflurazepam?

The production of N-Desalkylflurazepam mainly depends on the supply of chemical raw materials and the corresponding processing technology of N-Desalkylflurazepam. N-desalkyl-2-oxoquazepam (N-desalkylflurazepam) can be determined by specific GLC methods.

Before producing N-Desalkylflurazepam, you need to purchase the corresponding chemical raw materials.